Perindopril and ramipril phosphonate analogues as a new class of angiotensin converting enzyme inhibitors

Catherine Gomez; Sabine Berteina-Raboin; Guillaume De Nanteuil; Gérald Guillaumet

doi:10.1016/j.bmc.2013.08.032

Perindopril and ramipril phosphonate analogues as a new class of angiotensin converting enzyme inhibitors

Bioorg Med Chem. 2013 Nov 15;21(22):7216-21. doi: 10.1016/j.bmc.2013.08.032. Epub 2013 Sep 11.

Authors

Catherine Gomez¹, Sabine Berteina-Raboin, Guillaume De Nanteuil, Gérald Guillaumet

Affiliation

¹ Institut de Chimie Organique et Analytique, Université d'Orléans, UMR CNRS 7311, rue de Chartres, BP 6759, 45067 Orléans Cedex 2, France.

PMID: 24095015
DOI: 10.1016/j.bmc.2013.08.032

Abstract

A series of phosphonate analogues related to perindopril and ramipril were prepared and tested to estimate their ability to inhibit angiotensin converting enzyme. These new synthesized compounds were active ACE inhibitors with a promising activity.

Keywords: Angiotensin converting enzyme; Hypertension; Inhibitors; Phosphonate.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Angiotensin-Converting Enzyme Inhibitors / chemical synthesis
Angiotensin-Converting Enzyme Inhibitors / chemistry*
Angiotensin-Converting Enzyme Inhibitors / metabolism
Angiotensin-Converting Enzyme Inhibitors / pharmacology*
Binding Sites
Catalytic Domain
Enzyme Activation / drug effects
Humans
Molecular Docking Simulation
Organophosphonates / chemistry*
Peptidyl-Dipeptidase A / chemistry
Peptidyl-Dipeptidase A / metabolism
Perindopril / analogs & derivatives*
Perindopril / chemical synthesis
Perindopril / metabolism
Perindopril / pharmacology*
Protein Binding
Ramipril / analogs & derivatives*
Ramipril / chemical synthesis
Ramipril / metabolism
Ramipril / pharmacology*
Stereoisomerism

Substances

Angiotensin-Converting Enzyme Inhibitors
Organophosphonates
ACE protein, human
Peptidyl-Dipeptidase A
Ramipril
Perindopril